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The most common side effects of colchicine capsules include abdominal paindiarrheanauseaand vomiting.

Physicians should ensure that patients are suitable candidates for treatment with colchicine capsules and remain alert for signs and symptoms of toxic reactions associated with increased colchicine exposure due to drug interactionsSigns and symptoms of colchicine toxicity should be evaluated promptly andif toxicity is suspectedcolchicine capsules should be discontinued immediately.

The first stage of acute colchicine toxicity typically begins within 24 hours of ingestion and includes gastrointestinal symptoms such as abdominal painnauseavomitingdiarrheaand significant fluid lossleading to volume depletionPeripheral leukocytosis may also be seenLife-threatening complications occur during the second stagewhich occurs 24 to 72 hours after drug administrationattributed to multi-organ failure and its associated consequencesDeath usually results from respiratory depression and cardiovascular collapseIf the patient survivesrecovery of multi-organ injury may be accompanied by rebound leukocytosis and alopecia starting about 1 week after the initial ingestionTreatment of colchicine overdose should begin with gastric lavage and measures to prevent shockOtherwisetreatment is symptomatic and supportiveNo specific antidote is knownColchicine is not effectively removed by hemodialysisSee Pharmacokinetics

Myelosuppressionleukopeniagranulocytopeniathrombocytopeniapancytopeniaand aplastic anemia have been reported with colchicine used in therapeutic doses.

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talk with your doctor before taking colchicine if you re also taking cholesterol drugs.