The major product at the end of the metabolic pathway is circulating dapoxetine n- oxide, which is a weak ssri and contributes no clinical effect.

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Dapoxetine is a safe and effective treatment for premature ejaculationPEbut it has a high discontinuation rateaccording to new research.

There are three basic mechanisms involved in normal ante-grade ejaculationemissionexpulsionand orgasmand each of these components possesses separate neural pathwaysEjaculatory dysfunction can result from disruption of any point in this cascade of eventsSeveral recent studies have clarified some aspects of the physiology of ejaculationEmissionwhich begins with closure of the bladder neck to prevent retrograde flow of seminal fluid and sperm into the bladderrefers to the deposition of seminal fluid and sperm from the distal epididymisvas deferensseminal vesiclesand prostate into the posterior urethraWitt and Grantmyre 1993

This communication will . focus on the prevalenceetiologypathophysiologyand the current treatment options for PEMore specificallya novel selective serotonin reuptake inhibitorSSRIdapoxetinewill be evaluated for its pharmacokineticsefficacyand safety record in light of available preclinical and clinical data.

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