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Patients with renal insufficiency may develop hypocalcaemia or hypercalcaemiaRenagel does not contain calciumSerum calcium levels should be monitored as is done in normal follow-up of a dialysis patientElemental calcium should be given as a supplement in case of hypocalcaemia.
The safety of sevelamer hydrochloride has not been established in pregnant womenIn animal studies there was no evidence that sevelamer induced embryo-foetal toxicityRenagel should only be given to pregnant women if clearly needed and after a careful risk/benefit analysis has been conducted for both the mother and the foetussee section 5.3
During post marketing experiencevery rare cases of increased thyroid stimulating hormoneTSHlevels have been reported in patients co-administered sevelamer hydrochloride and levothyroxineCloser monitoring of TSH levels is therefore recommended in patients receiving both medicinal products.
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