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Oedemahypertension and cardiac failurehave been reported in association with NSAID treatmentClinical trial and epidemiological data suggest that use of some NSAIDsparticularly at high doses and in long term treatmentmay be associated with an increased risk of arterial thrombotic eventsfor example myocardial infarction or strokesee section 4.4
Appropriate monitoring and advice are required for patients with a history of hypertension and/or mild to moderate congestive heart failure as fluid retention and oedema have been reported in association with NSAID therapy.
The . elimination half-life averages seven hours in manThe primary route of excretion is in the urinemostly in the form of metabolites.
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