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LASSBio-772a 1,3-benzodioxole N-phenylpiperazine derivative a novel potent and selective alpha 1 A1 D adrenoceptorARantagonist selected after screening of functionalized N-phenylpiperazine derivatives in phenylephrine-induced vasoconstriction of rabbit aorta ringsThe affinity of LASSBio-772 for alpha 1 A and alpha 1 B AR subtypes was determined through displacement of3 H]prazosin bindingThis compound presents pharmacological features higher affinity for the alpha 1 A1 D than alpha 1 BARbeing therefore putatively useful for the treatment of the LUTSincluding the BPH in mammals71]
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Small CaltropsGokshurais useful in treating BPHgenitourinary infectionspainful urinationhematuria and dysuria.
1 or 2 tablets twice daily with meals.Allow several weeks for benefitsThe use of natural products provides progressive but long-lasting results.
Cerniltonprepared from the rye-grass pollen Secale cerealeis one of several phytotherapeutic agents available for the treatment of BPHIt is used by millions of men worldwide and is a registered pharmaceutical product throughout Western EuropeJapanKorea and ArgentinaThe Cernilton trials analysed were limited by their short durationlimited number of enroleesomissions in reported outcomesand the unknown quality of the preparations usedThe comparative trials had no confirmed active controlThe available . evidence suggests that Cernilton is well tolerated and modestly improves overall urological symptomsincluding nocturia49]
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