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Serious neurologic eventssome resulting in deathhave been reported with epidural injection Specific events reported includebut are not limited tospinal cord infarctionparaplegiaquadriplegiacortical blindnessand stroke These serious neurologic events have been reported with and without use of fluoroscopy Safety and effectiveness of epidural administration of corticosteroids have not been establishedand corticosteroids are not approved for this use.

Treatment of overdosage is by supportive and symptomatic therapyIn the case of acute overdosageaccording to the patient’s conditionsupportive therapy may include gastric lavage or emesis.

Concomitant use of aspirinor other nonsteroidal anti-inflammatory agentsand corticosteroids increases the risk of gastrointestinal side effectsAspirin should be used cautiously in conjunction with corticosteroids in hypoprothrombinemiaThe clearance of salicylates may be increased with concurrent use of corticosteroids.

Use of oral corticosteroids not recommended in treatment of optic neuritis and may lead to increase in risk of new episodescorticosteroids should not be used in active ocular herpes simplex.

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