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Stimats xposu multipls compaing animal studis tth MHD dutastid a basd on clinical sum concntation at stady stat.

AVODAT is containdicatd us in womn childbaing potntial and duing pgnancy. AVODAT is a 5 alpha-ductas inhibitthat pvnts convsion tstoston tdihydotstoston (DHT), a homon ncssay nomal dvlopmnt mal gnitalia. In animal poduction and dvlopmntal toxicity studis, dutastid inhibitd nomal dvlopmnt xtnal gnitalia in mal tuss. Tho, AVODAT may caus tal ham whn administd ta pgnant woman. I AVODAT is usd duing pgnancy i th patint bcoms pgnant whil taking AVODAT, th patint should b appisd th potntial hazad tth tus.

Dutastid is xtnsivly mtabolizd in humans by th CYP3A4 and CYP3A5 isonzyms. Th ct potnt CYP3A4 inhibitos on dutastid has not bn studid. Bcaus th potntial dug-dug intactions, us caution whn pscibing AVODAT tpatints taking potnt, chonic CYP3A4 nzym inhibitos (.g., itonavi) [s CLINICAL PHAMACOLOGY ].

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