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Celecoxib is a potent inhibitor of prostaglandin synthesis in vitroCelecoxib concentrations reached during therapy have produced in vivo effectsProstaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal modelsProstaglandins are mediators of inflammationSince celecoxib is an inhibitor of prostaglandin synthesisits mode of action may be due to a decrease of prostaglandins in peripheral tissues.

Centralperipheral Leg crampshypertoniahypoesthesianervous systemmigraineparesthesiavertigo.

Get emergency medical help if you have signs of an allergic reaction to Celebrexsneezingrunny or stuffy nosewheezing or trouble breathinghivesswelling of your facelipstongueor throat.

To minimize the potential risk for an adverse CV event in NSAID-treated patientsuse the lowest effective dose for the shortest duration possiblePhysicians and patients should remain alert for the development of such eventsthroughout the entire treatment courseeven in the absence of previous CV symptomsPatients should be informed about the symptoms of serious CV events and the steps to take if they occur.

Other side effects of NSAIDs includestomach painconstipationdiarrheagasheartburnnauseavomitingand dizziness.

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the fda ruled that the benefits of celebrex outweighed the risks, but decided that bextra had to go, when the agency received reports of seven deaths from serious skin reactions.