Thioridazine because tremors may be worsened in parkinson patients anticholinergics eg, scopolamine , hydrochlorothiazide, quinidine, quinine, stimulants eg, caffeine, methylphenidate, pseudoephedrine , or triamterene because they may increase the risk of amantadine s side effects.

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Fluid and electrolyte imbalances are the most important concernExcessive doses of the triamterene component may elicit hyperkalemiadehydrationnauseavomiting and weakness and possibly hypotensionOverdosing with hydrochlorothiazide has been associated with hypokalemiahypochloremiahyponatremiadehydrationlethargymay progress to comaand gastrointestinal irritationTreatment is symptomatic and supportiveTherapy with MAXZIDEtriamterene and hydrochlorothiazideshould be discontinuedInduce emesis or institute gastric lavageMonitor serum electrolyte levels andfluid balance.

CarcinogenesisLong-term studies with MAXZIDEthe triamterene/hydrochlorothiazide combinationhave not been conducted.

Fluid and electrolyte imbalances are the most important concernExcessive doses of the triamterene component may elicit hyperkalemiadehydrationnauseavomiting and weakness and possibly hypotensionOverdosing with hydrochlorothiazide has been associated with hypokalemiahypochloremiahyponatremiadehydrationlethargymay progress to comaand gastrointestinal irritationTreatment is symptomatic and supportiveTherapy with MAXZIDEtriamterene and hydrochlorothiazideshould be discontinuedInduce emesis or institute gastric lavageMonitor serum electrolyte levels and fluid balance.

In patients requiring hydrochlorothiazide therapy and in whom hypokalemia cannot be risked therapy may be initiated with MAXZIDE-25 MGIf an optimal blood pressure response is not obtained with MAXZIDE-25 MGthe dose should be increased to two MAXZIDE-25 MG tablets daily as a single doseor one MAXZIDE tablet dailyIf blood pressure still is not controlledanother antihypertensive agent may be addedsee PRECAUTIONSDRUG INTERACTIONS

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