The mechanism of action of macrolides is inhibition of bacterial protein biosynthesis, and they are thought to do this by preventing peptidyltransferase from adding the peptidyl attached to trna to the next amino acid similarly to chloramphenicol as well as inhibiting ribosomal translocation.

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Information about Chloramphenicol.

Chloramphenicol may be absorbed systemically following the use of eye ointment and may cross the placenta and appear in breast milkTherefore this product is not recommendedfor use during pregnancy and lactation.

Accidental overdose or accidental ingestion of the ointment is unlikely to cause systemic toxicity due to low content of chloramphenicol in the product.

Use chloramphenicol as ordered by your doctorRead all information given to youFollow all instructions closely.

If you suspect that someone might have swallowed some of this medicinecontact your local accident and emergency department for advice.

Most cases of infective conjunctivitis clear within a few days without treatmentFor more severe infectionsor for infections which do not clear on their ownan antibiotic eye drop or ointment such as chloramphenicol can be helpful.

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interestingly, it later transpired that her daughter had also suffered adverse reactions to chloramphenicol.