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This medication may rarely cause an inflammation of the heart musclemyocarditisor heart failureGet medical help right away if you develop chest painfast/irregular heartbeatshortness of breathswelling ankles/feetunusual tirednessor unusual/sudden weight gain.

There may be a slightly increased risk of seriouspossibly fatal side effectssuch as strokeheart failurefast/irregular heartbeatpneumoniawhen this medication is used by older adults with dementiaThis medication is not approved for the treatment of dementia-related behavior problemsDiscuss the risks and benefits of this medicationas well as . other effective and possibly safer treatments for dementia-related behavior problemswith the doctor.

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it may be necessary to reduce the clozaril dose in patients with significant renal or hepatic impairment, or in cyp2d6 poor metabolizers see use in specific populations .