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Since cyclophosphamide has been reported to be more toxic in adrenalectomized dogsadjustment of the doses of both replacement steroids and cyclophosphamide may be necessary for the adrenalectomized patient.

Handle and. dispose of cyclophosphamide in a manner consistent with other cytotoxic drugs1 Caution should be exercised when handling and preparing Cyclophosphamide for InjectionUSPlyophilized powderor bottles containing cyclophosphamide tabletsTo minimize the risk of dermal exposurealways wear gloves when handling vials containing Cyclophosphamide for InjectionUSPlyophilized powderor bottles containing cyclophosphamide tabletsThe coating of the cyclophosphamide tablets prevents direct contact of persons handling the tablets with the active substanceHoweverto prevent inadvertent exposure to the active substancethe cyclophosphamide tablets should not be cutchewedor crushedPersonnel should avoid exposure to broken tabletsIf contact with broken tablets occurswash hands immediately and thoroughly.

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