There were no significant differences in asthma symptom scores and mean change from baseline in an asthma symptom score between ventolin hfa 180 mcg and ventolin hfa 360 mcg.

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VENTOLIN HFAlike all other beta2adrenergic agonistscan produce clinically significant cardiovascular effects in some patients such as changes in pulse rate or blood pressureIf such effects occurVENTOLIN HFA may need to be discontinuedIn additionbeta-agonists have been reported to produce electrocardiogramECGchangessuch as flattening of the T waveprolongation of the QTc intervaland ST segment depressionThe clinical relevance of these findings is unknownThereforeVENTOLIN HFAlike all other sympathomimetic aminesshould be used with caution in patients with underlying cardiovascular disordersespecially coronary insufficiencycardiac arrhythmiasand hypertension.

Immediate hypersensitivity reactionse.gurticariaangioedemarashbronchospasmhypotensionincluding anaphylaxismay occur after administration of VENTOLIN HFAsee CONTRAINDICATIONS

VENTOLIN HFAlike other sympathomimetic aminesshould be used with caution in patients with convulsive disordershyperthyroidismor diabetes mellitus and in patients who are unusually responsive to sympathomimetic aminesLarge doses of intravenous albuterol have been reported to aggravate preexisting diabetes mellitus and ketoacidosis.

The blue actuator supplied with VENTOLIN HFA should not be used with any . other product canistersand actuators from other products should not be used with a VENTOLIN HFA canister.

VENTOLIN HFA can produce paradoxical bronchospasmwhich may be life threateningIf paradoxical bronchospasm occurs following dosing with VENTOLIN HFAit should be discontinued immediately and alternative therapy should be institutedIt should be recognized that paradoxical bronchospasmwhen associated with inhaled formulationsfrequently occurs with the first use of a new canister.

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