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After reconstitutionCOUMADIN for injection is stable for 4 hours at room temperatureIt does not contain any antimicrobial preservative andthuscare must be taken to assure the sterility of the prepared solutionThe vial is for single use onlydiscard any unused solution.

The appropriate initial dosing of COUMADIN varies widely for . different patientsNot all factors responsible for warfarin dose variability are knownand the initial dose is influenced by:

In a prospectiverandomizedopen-labelpositive-controlled study in 254 patients with mechanical prosthetic heart valvesthe thromboembolic-free interval was found to be significantly greater in patients treated with warfarin alone compared with dipyridamole/aspirin-treated patientsp.

Take Coumadin exactly as prescribed by your doctorFollow all directions on your prescription labelYour doctor may occasionally change your doseDo not take warfarin in larger or smaller amounts or for longer than your doctor tells you to.

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this can happen soon after starting coumadin.