Keppra 500 mg twice daily did not influence the pharmacokinetics of an oral contraceptive containing 0.

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KEPPRA may cause behavioral abnormalities and psychotic symptomsPatients treated with KEPPRA should be monitored for psychiatric signs and symptoms.

Table 3 lists adverse reactions that occurred in at least 1of adult epilepsy patients receiving KEPPRA in placebocontrolled studies and were numerically more common than in patients treated with placeboIn these studieseither KEPPRA or placebo was added to concurrent AED therapy.

Patientstheir caregiversand families should be informed that AEDs increase the risk of suicidal thoughts and behavior and should be advised of the need to be alert for the emergence or worsening of the signs and symptoms of . depressionany unusual changes in mood or behavioror the emergence of suicidal thoughtsbehavioror thoughts about selfharmBehaviors of concern should be reported immediately to healthcare providers.

There have been isolated reports of decreased levetiracetam efficacy when the osmotic laxative macrogol has been concomitantly administered with oral levetiracetamThereforemacrogol should not be taken orally for one hour before and for one hour after taking levetiracetam.

There have been isolated reports of decreased levetiracetam efficacy when the osmotic laxative macrogol has been concomitantly administered with oral levetiracetamThereforemacrogol should not be taken orally for one hour before and for one hour after taking levetiracetam.

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patients, their caregivers, and families should be counseled that aeds, including keppra, may increase the risk of suicidal thoughts and behavior and should be advised of the need to be alert for the emergence or worsening of symptoms of depression, any unusual changes in mood or behavior, or the emergence of suicidal thoughts, behavior, or thoughts about self-harm.