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Drugs that affect the absorptiondistributionmetabolismand excretion of ketoconazole may alter the plasma concentrations of ketoconazoleFor examplegastric acid suppressantse.gantacidshistamine H2-blockersproton pump inhibitorshave been shown to reduce plasma concentrations of ketoconazole.
Co-administration of the following drugs with ketoconazole is contraindicateddofetilidequinidinepimozidecisaprideKetoconazole can cause elevated plasma concentrations of these drugs and may prolong QT intervalssometimes resulting in life-threatening ventricular dysrhythmias such as torsades de pointesSee CONTRAINDICATIONSWARNINGSand PRECAUTIONSDRUG INTERACTIONS sections.
Immune System Disordersallergic conditions including anaphylactic shockanaphylactic reactionangioneurotic edema.
Ketoconazole is not for use in treating fungal infections of the fingernails or toenailsThis medicine is also not for use in treating prostate cancer or Cushing syndrome.
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