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During treatment initiation and dose titrationsee belowone-hour postprandial plasma glucose may be used to determine the therapeutic response to Precose and identify the minimum effective dose for the patientThereafterglycosylated hemoglobin should be measured at intervals of approximately three monthsThe therapeutic goal should be to decrease both postprandial plasma glucose and glycosylated hemoglobin levels to normal or near normal by using the lowest effective dose of Precoseeither as monotherapy or in combination with sulfonylureasinsulin or metformin.
There have been rare postmarketing reports of pneumatosis cystoides intestinalis associated with the use of alpha-glucosidase inhibitorsincluding PrecosePneumatosis cystoides intestinalis may present with symptoms of diarrheamucus dischargerectal bleedingand constipationComplications may include pneumoperitoneumvolvulusintestinal obstructionintussusceptionintestinal hemorrhageand intestinal perforationIf pneumatosis cystoides intestinalis is suspecteddiscontinue Precose and perform the appropriate diagnostic imaging.
The recommended starting dosage of PRECOSE is 25 mg given orally . three times daily at the startwith the first biteof each main mealHoweversome patients may benefit from more gradual dose titration to minimize gastrointestinal side effectsThis may be achieved by initiating treatment at 25 mg once per day and subsequently increasing the frequency of administration to achieve 25 mg t.i.d.
Clinical Experience in Type 2 Diabetes Mellitus Patients on Monotherapyor in Combination with SulfonylureasMetformin or InsulinPrecose was studied as monotherapy and as combination therapy to sulfonylureametforminor insulin treatmentThe treatment effects on HbA1c levels and one-hour postprandial glucose levels are summarized for four placebo-controlleddouble-blindrandomized studies conducted in the United States in Tables 2 and 3respectivelyThe placebo-subtracted treatmentdifferenceswhich are summarized belowwere statistically significant for both variables in all of these studies.
Inflammatory bowel diseasea blockage in your intestinesa digestive disorder affecting your intestinesintestinal ulcerof your colonor cirrhosis of the liver.
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