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Elevations of ALT or ASTthree or more times the upper limit of normalULNhave been reported in approximately 1of NSAID-treated patients in clinical trialsIn additionraresometimes fatalcases of severe hepatic injuryincluding fulminant hepatitisliver necrosisand hepatic failure have been reported.
Celebrex may also cause stomach or intestinal bleedingwhich can be fatalThese conditions can occur without warning while you are using Celebrexespecially in older adultsYou should not take this medicine if you already have bleeding in your stomach or intestines.
A subpopulation of patients with asthma may have aspirin-sensitive asthma which may include chronic rhinosinusitis complicated by nasal polypsseverepotentially fatal bronchospasmand/or intolerance to aspirin and other NSAIDsBecause cross-reactivity between aspirin and other NSAIDs has been reported in such aspirin-sensitive patientsCELEBREX is contraindicated in patients with this form of aspirin sensitivitysee CONTRAINDICATIONSWhen CELEBREX is used in patients with preexisting asthmawithout known aspirin sensitivitymonitor patients for changes in the signs and symptoms of asthma.
Monitor blood pressureBPduring the initiation of NSAID treatment and throughout the course of therapy.
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