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KEPPRA is given orally with or without foodThe KEPPRA dosing regimen depends on the indicationage groupdosage formtablets or oral solutionand renal function.

A saturable and stereoselective neuronal binding site in rat brain tissue has been described for levetiracetamExperimental data indicate that this binding site is the synaptic vesicle protein SV2Athought to be involved in the regulation of vesicle exocytosisAlthough the molecular significance of levetiracetam binding to SV2A is not understoodlevetiracetam and related analogs showed a rank order of affinity for SV2A which correlated with the potency of their antiseizure activity in audiogenic seizure-prone miceThese findings suggest that the interaction of levetiracetam with the SV2A protein may contribute to the antiepileptic mechanism of action of the drug.

Partial-onset seizures with or without generalisation in patients from one month of agemyoclonic seizuresshortshock-like jerks of a muscle or group of musclesin patients from 12 years of age with juvenile myoclonic epilepsyprimary generalised tonic-clonic seizuresmajor fitsincluding loss of consciousnessin patients from 12 years of age with idiopathic generalised epilepsythe type of epilepsy that is thought to have a genetic cause

KEPPRA tablets should be swallowed wholeKEPPRA tablets should not be chewed or crushed.

The following adverse reactions are discussed in more details in other sections of labeling:

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