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Elderly . subjects may commonly have conditions that may be exacerbated by fludrocortisone therapy includingbut not limited tohypertensionedemahypokalemiacongestive heart failurecataractsglaucomaincreased intraocular pressurerenal insufficiencyand osteoporisissee WARNINGSPRECAUTIONS and ADVERSE REACTIONSElderly subjects may also commonly be taking concomitant drug therapy such as digitalis glycosidesoral anticoagulantsantidiabetic drugsoral agents and insulinand aspirin which may interact with fludrocortisonesee PRECAUTIONSDrug Interactions
Growth and development of infants andchildren on prolonged corticosteroid therapy should be carefully observed.
Development of hypertensionedemahypokalemiaexcessive increase in weightand increase in heart size are signs of overdosage of fludrocortisone acetateWhen these are notedadministration of the drug should be discontinuedafter which the symptoms will usually subside within several dayssubsequent treatment with fludrocortisone acetate should be with a reduced doseMuscular weakness may develop due to excessive potassium loss and can be treated by administering a potassium supplementRegular monitoring of blood pressure and serum electrolytes can help to prevent overdosagesee WARNINGS
Corticosteroids should be used cautiously in patients with ocular herpes simplex because of possible corneal perforation.
Adverse reactions to corticosteroids may be produced by too rapid withdrawal or bycontinued use of large doses.
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