Because olanzapine is highly metabolized before excretion and only 7 of the drug is excreted unchanged, renal dysfunction alone is unlikely to have a major impact on the pharmacokinetics of olanzapine.
Information about Olanzapine.
During antipsychotic treatmentimprovement in the patient’s clinical condition may take several days to some weeksPatients shouldbe closely monitored during this period.
May induce orthostatic hypotension associated with dizzinesstachycardiabradycardia andin some patientssyncopeespecially during initial dose-titration periodprobably as consequence of alpha1-adrenergic antagonistic properties.
A lower starting dose5 mgshould be considered for such patientsIn cases of moderate hepatic insufficiencycirrhosisChild-Pugh Class A or Bthe starting dose should be 5 mg and only increased with caution.
An injectable form is also availableThis form is given only by a healthcare provider.
A lower starting dose5 mgshould be considered for such patientsIn cases of moderate hepatic insufficiencycirrhosisChild-Pugh Class A or Bthe starting dose should be 5 mg and only increased with caution.
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nausea was also improved with olanzapine, although almost half the participants still had nausea in the delayed phase.
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