Sinemet cr should be substituted at a dosage that will provide approximately 25 of the previous levodopa dosage see dosage and administration .
Information about Sinemet.
Patients with chronic wide-angle glaucoma may be treated cautiously with SINEMET provided the intraocular pressure is well-controlled and the patient is monitored carefully for changes . in intraocular pressure during therapy.
The amount of levodopa absorbed by the body may be impaired if you eat a diet high in proteinAsk your doctorpharmacist or dietician to check your diet.
Patients should be alerted to the possibility of sudden onset of sleep during daily activitiesin some cases without awareness or warning signswhen they are taking dopaminergic agentsincluding levodopaPatients should be advised to exercise caution while driving or operating machinery and that if they have experienced somnolence and/or sudden sleep onsetthey must refrain from these activitiesSee WARNINGSFalling Asleep During Activities of Daily Living and Somnolence
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starting dosage is one tablet of sinemet 25-100 carbidopa-levodopa three times a day.
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