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The elimination half-life of domperidone is prolonged in severe renal impairmentFor repeated administrationthe dosing frequency of Motilium should be reduced to once or twice daily depending on the severity of the impairmentThe dose may also . need to be reduced.
The Medicines and Healthcare Products Regulatory Agency issued the updated advice following the review by the European Medicines Agency.
Domperidone containing products must not be sold to anyone without a prescriptionThis medicine is associated with a small increased risk of serious cardiac effectshence patients need to have a medical assessment before taking domperidone to determine whether it is suitable for themplease see further details in the appendix
For the short term treatment in adults of1Symptoms associated with idiopathic or diabetic gastroparesis(once control of diabetes has been established by diet and/or insulinattempt should be made to discontinue MOTILIUM2Intractable nausea and vomiting from any cause.
It was found there have been 342 reports of serious side effects and 57 people known to have died from heart problems while taking domperidone.
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