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Serious cardiac eventsincluding some that have been fatalhave occurred following use of 5-HT 1 agonistsThese events are extremely rare and most have been reported in patients with risk factors predictive of CADEvents reported have included coronary artery vasospasmtransient myocardial ischaemiamyocardial infarctionventricular tachycardia and ventricular fibrillation.

Serious cardiac eventsincluding some that have been fatalhave occurred following use of 5-HT 1 agonistsThese events are extremely rare and most have been reported in patients with risk factors predictive of CADEvents reported have included coronary artery vasospasmtransient myocardial ischaemiamyocardial infarctionventricular tachycardia and ventricular fibrillation.

Rizatriptan should be used with caution in dialysis patients due to a decrease in the clearance of rizatriptan.

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Angio-oedemae.gfacial oedematongue swelling and pharyngeal oedemamay occur in patients treated with triptanssuch as rizatriptanIf angio-oedema of the tongue or pharynx occursthepatient should be placed under medical supervision until the symptoms have resolvedTreatment should promptly be discontinued and replaced by an agent belonging to another class of drugs.

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